Springfield is well served by Memorial Medical Center, St John's Hospital and SIU School of Medicine.

The flagship of the Memorial Health System, this acute care hospital with 562 licensed beds and more than 3,500 employees offers comprehensive inpatient and outpatient services. Memorial Medical Center is committed to finding innovative alternatives to traditional hospital care. Memorial, located in Springfield, Illinois, is a teaching hospital, affiliated with Southern Illinois University School of Medicine. Memorial has over 550 physicians on staff.

SIU School of Medicine is a state-assisted school established in 1970 to help the people of central and southern Illinois in meeting their health care needs through education, research and service. Illinois benefits greatly from the commitment of SIU's faculty and staff. The School of Medicine is working to train caring and competent physicians and develop new models for providing health care in rural areas.

St. John's Hospital in Springfield is a regional healthcare center serving central and southern Illinois. The hospital is licensed for over 700 beds, making it the largest hospital in downstate Illinois. Founded in 1875 by the Hospital Sisters of the Third Order of St. Francis, it is also one of the largest Catholic hospitals in the United States.

Over 600 physicians representing approximately 30 specialties and sub-specialties are on the medical staff. St. John's serves as a teaching hospital for Southern Illinois University School of Medicine residents and medical students. The hospital also supports other areas of medical careers education: nursing, dietetics, ENDT, medical technology and respiratory therapy.